Phatthanaphong Wanchanthuek

Contact Details

Office:	Murdoch Campus, BITL Building, Room 3.002
Phone Number:	+61 8 9360 2790
Fax Number:	+61 8 9360 7238
Mailing Address:	Centre for Comparative Genomics, Murdoch University, Perth, Western Australia, 6150, Australia
E-Mail Address:	pwanch@ccg.murdoch.edu.au
Current Rroject:	Detailed comparative genomics to investigate genome evolution of the newly sequence Brachyspira hyodysenteriae and Brachyspira pilosicoli

Project Description: Whole genomic sequence data from the pathogenic intestinal spirochaetes Brachyspira hyodysenteriae and Brachyspira pilosicoli will be subjected to extensive comparative genomic analysis to help identify potential virulence factors for these two species. Analysis will include comparisons with other species of pathogenic bacteria. Genes theoretically identified as having potential to contribute to virulence will be assessed for their distribution across the genus. These will then be cloned, and recombinant products produced and further characterised. Gene inactivation studies will be carried out, and Brachyspira strains with mutations induced in these genes will be tested for their ability to contribute to bacterial colonisation and induction of disease. Gene products will be tested for their immunogenicity and capacity to induce protective immunity in animals, and hence as vaccine components.

Informations

Qualifications

Research Student (System Biology) Kyushu Institue of Technology, Japan
M. Eng. (Bioinformatics) Technical University of Denmark, Denmark
M. Sc. (Biotechnology) Kasetsart Univeristy, Thailand

Research Interests

I am interested include Molecular Evolution, Gene Annotation, Comparative Genomics and Systems Biology.

Publications

Book Chapter

Wanchanthuek, P, P F Hallin, RG Oliveira and D Ussery. 2005. Structural Features of Fungal Genomes. Topic in Current Genetics, Publisher: Springer Berlin/Heidelberg ISSN: 1610-2096. 11 November, 2005. Abstract Full text

Full publications

Wanchanthuek, P., Dunn, DS., M., La, T., Hampson, D.J., and Bellgard, M. 2008. The investigation of overlapping genes in Spirochaete genomes. (in preparation)
Wanchanthuek, P., Dunn, DS., Y., La, T., Hampson, D.J., and Bellgard, M. 2008. Comparative analysis of overlapping genes of Brachyspira hyodysenteriae and Brachyspira pilosicoli. (in preparation)
Wanchanthuek, P., Dunn, DS., La, T., Hampson, D.J., and Bellgard, M. 2008. Coexpression of overlapping genes in the metabolic pathways of Brachyspira hyodysenteriae and Brachyspira pilosicoli. (in preparation)
Wanchanthuek, P., Dunn, DS., La, T., Hampson, D.J., and Bellgard, M. 2008. Multilocus sequence typing analysis and comparative evolution of housekeeping genes of Brachyspira hyodysenteriae. (in preparation)
Prathumpai, W, B Gabelgaard, P Wanchanthuek, P van de Vondervoort, M de Groot, McIntyre, M and Nielsen, J. 2003. Metabolic control analysis for xylose catabolism in Aspergillus. Biotechnology Progress 19: 1136-1141.Abstract

Posters

Wanchanthuek, P, PF Hallin, and D Ussery. 2004. Bioinformatics analysis of 18 fungal genomes. 3rd -6th June 2004 Bioinformatics conference, Linköping, Sweden.
Wanchanthuek, P, M Rodprapakon, C Chettanachit and S Bhuwapathanaphun. 2000. Bacterial cellulose production on pineapple milled juice by selected strain of Acetobacter sp. The 12th Annual Meeting of the Thai Society of Biotechnology, Felix hotel, Kanjanaburee, Thailand.
Wanchanthuek, P, M Rodprapakon, C Chettanachit and S Bhuwapathanaphun. 2001. Effect of pH on bacterial cellulose production on pineapple-milled juice by selected strain of Acetobacter sp. The 39th Annual Meeting of Kasetsart University Conference, Thailand. Full text
Techaphun, C, P Seesuriyachan, P Wanchanthuek and N Poosarun. 2000. Study of mass and energy balances: regularity in biomass and ethanol productions by Saccharomyces sake in various carbon sources. The 12th Annual Meeting of the Thai Society of Biotechnology, Felix hotel, Kanjanaburee, Thailand.