Comparative Genomics
A selected number of CCG comparative genomic projects are briefly outlined below
Reverse Vaccinology and Molecular Evolution
The CCG (in collaboration with the Veterinary and Biomedical Sciences Department at Murdoch University and an industry partner) is currently sequencing (outsourced) and annotating two whole bacterial genomes (pathogenic spirochaetes species) with a view to identifing viable vaccine candidates. A number of other comparative genomic and molecular evolution studies are also underway.
Wheat Genome Sequencing and Annotation
The bread wheat genome (Triticum aestivum) presents a challenge in genome sequencing and annotation due to its large size (~17 Gb), hexaploid nature, and repetitive sequence content (>90%). Chromosome 3B is currently a major focus with a 3B-specific 70,000 BAC clone library contig'd, and selected regions of the chromosome being sequenced, through a concerted international collaboration including the CCG.
LegumeDB Bioinformatics Resource
LegumeDB is a web-based bioinformatics resource for comparative genomic analysis developed at the CCG. This curated resource enables data storage and visualization of numerous sequence analyses (and re-analyses) from diverse / customized database sets and alignment programs.
Features such sequence alignments, genes and markers can be integrated and visualized in LegumeDB's genetic and physical comparative maps.
LegumeDB in-silico markers can be designed spanning intron and SSR regions in genomic and cDNA based on conserved sequence alignments with a number of different legume species. more ...
MHC evolution
Studies are currently underway to investigate the structure, function, expression and evolution of the MHC as well as to identify and characterise the genes involved in diseases such as hypertension, high myopia, psoriasis, skin cancers, asthma and other diseases.
Comparative genomics between different human haplotypes and species is an important strategy for elucidating the structure, function and evolution of the 240 coding and non-coding human MHC genes.
Identifying viable RNAi targets for the Cattle Tick
As part of the Beef CRC, a project is underway to identify RNAi targets suitable as vaccine candidates in the Cattle Tick Rhipicephalus microplus utilising available EST sequences to model whole genome sequences.
Annotating whole genomes via a Computing GRID
As part of the Australian Partnership for Advanced Computing (APAC) a project is underway to undertake whole genome annotation utilising High Performance Computers located around Australia.
Truth in Labelling of Fish: An integrated Proteomics and Bioinformatics approach
A new project is underway to investigate integrating a Bioinformatics and Proteomics approach to assist in classification of Fish species. The project is funded by the Australian Research Council.
